Using Low-Molecular-Weight Heparins in Infants and Children
نویسنده
چکیده
The medication we know as heparin is actually a heterogeneous mixture of polysaccharides derived from beef or pork livers. Although the exact mechanism for heparin’s antithrombotic properties is not known, it is believed to act by binding to antithrombin III. The heparinantithrombin III complex inhibits the activity of numerous enzymes in the clotting cascade, including factors IIa (thrombin), IXa, Xa, XIa, and XIIa. 1-5 In addition, heparin induces release of other endogenous antithrombotic substances, such as tissue factor pathway inhibitor and tissue plasminogen activator.
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